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Respiratory disorders: Ironing out smoking-related airway disease

Journal name:
Nature
Volume:
531,
Pages:
586–587
Date published:
DOI:
doi:10.1038/nature17309
Published online

Lack of the protein IRP2 in mice prevents organelles called mitochondria from accumulating toxic levels of iron in response to smoke exposure. This discovery links environmental and genetic risk factors for a chronic lung disease.

References

  1. Johnson, N. B., Hayes, L. D., Brown, K., Hoo, E. C. & Ethier, K. A. MMWR Suppl. 63 (Suppl. 4), 327 (2014).
  2. Gordon, S. B. et al. Lancet Respir. Med. 2, 823860 (2014).
  3. Islam, J. Y., Keller, R. L., Aschner, J. L., Hartert, T. V. & Moore, P. E. Am. J. Respir. Crit. Care Med. 192, 134156 (2015).
  4. Weiss, S. T. Nature Genet. 42, 1416 (2010).
  5. Cloonan, S. M. et al. Nature Med. 22, 163174 (2016).
  6. Burrows, B., Knudson, R. J., Cline, M. G. & Lebowitz, M. D. Am. Rev. Respir. Dis. 115, 195205 (1977).
  7. Laurell, C.-B. & Eriksson, S. Scand. J. Clin. Lab. Invest. 15, 132140 (1963).
  8. Lieberman, J., Winter, B. & Sastre, A. Chest 89, 370373 (1986).
  9. Silverman, E. K. et al. Am. J. Hum. Genet. 70, 12291239 (2002).
  10. DeMeo, D. L. et al. Am. J. Hum. Genet. 85, 493502 (2009).
  11. Ghio, A. J. Biochim. Biophys. Acta 1790, 731739 (2009).
  12. Chen, C. & Paw, B. H. Biochim. Biophys. Acta 1823, 14591467 (2012).
  13. Aravamudan, B., Thompson, M. A., Pabelick, C. M. & Prakash, Y. S. Expert Rev. Respir. Med. 7, 631646 (2013).
  14. Dubey, S. & Powell, C. A. Am. J. Respir. Crit. Care Med. 179, 860868 (2009).

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Affiliations

  1. Thomas J. Mariani is in the Division of Neonatology and the Pediatric Molecular and Personalized Medicine Program, University of Rochester Medical Center, Rochester, New York 14642, USA.

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