No further comment.....R.Kiehl
Von: jow@soton.ac.uk jow@soton.ac.uk An: kiehl@rki-i.com
Betreff: Pediatric Allergy and Immunology - PAI-06-L-0014
Dear Prof. Reinhold Kiehl
We are very sorry to have to inform you that both our reviewers had serious concerns about the above paper and therefore we will be
unable to accept it for publication on this occasion. The reviewers' reports may help you with considering whether to submit the paper
elsewhere.
Kindest regards
Prof. John Warner
COMMENTS FOR THE AUTHOR:
Sadly, the author of this letter appears to be delivering a rebuke against the authors of a published paper for failing to quote his
contributions to the literature. It is then followed by a personal anecdote that has no place in the medical literature. The letter does not really
make any points particularly worthy of publication.
Pediatric Allergy and Immunology, Letter to the Editor, 21.11.05, corrected version
No, the severity of atopic dermatitis does not correlate with serum IgE levels!
Dear Editor,
I am wondering to a great extent about the paper by Laske and Niggemann (1) and the "Letter to the Editor" by Joishy et al
(2) addressing total serum IgE levels and severity of atopic dermatitis...I suggest to both groups to study the work on these
matters done by my groups during the years 1987 to 1998! For convenience the references cited are the best way to do so
(3 – 12).
The other point why I am wondering: How can a SCORAD score and total serum IgE level as shown in Fig.1 (1) be
interpreted as statistically highly significant, on the basis of p-value?
The authors of the letter (2) are correct in their argumentation - it needs no further point to clarify this matter...However I
should state again, the papers of mine (3-12) were addressing the now raised question (11).
A third point: I by myself got allergic problems and the level of total IgE in my serum samples are for sure not related to any
degree of eczema: At levels of total IgE as high as 1000 kU/l I had no sign of any skin manifestations – I had family
problems among other things (divorce, job) which relates to psychic factors.
The "Hyper-IgE-Syndrome" is not to correlate with dermatitis. Skin Prick-tests and Epicoutanous-tests do neither...
Anyhow...I suggest the measurement of total IgE in the serum of every person as predictive factor for disease development and preventive step.
References
Reinhold Kiehl, RKI-Institute, Saliterweg 1, D-93 437 Furth im Wald, phone: +49 9973 801056, kiehl@rki-i.com, www.rki-i.com, www.dr-kiehl.net.
----- Original Message ----- From: <jow@soton.ac.uk> To: <kiehl@rki-i.com> Cc: <paieditorial@soton.ac.uk> Sent: Wednesday, January 04, 2006 4:35 PM
Subject: Pediatric Allergy and Immunology - Manuscript PAI-06-L-0001
> Dear Prof. Reinhold Kiehl
>
> Thank you for the submission of the above letter to PAI.
> Unfortunately we are not able to publish a letter containing
> such personal and specifically pointed comments directed at
> other authors. Should you wish to make comment on the issues
> raised in the paper you mention please do submit another letter,
> but also only comment upon the scientific/clinical issues that
> concern you.
>
> Yours sincerely
>
>
>
> Prof. John Warner
> Editor in Chief
Pediatric Allergy and Immunology, Letter to the Editor, 21.11.05
No, the severity of atopic dermatitis does not correlate with serum IgE levels!
Dear Editor,
I am wondering to a great extent about the paper by Laske and Niggemann (1) and the "Letter to the Editor" by
Joishy et al (2) addressing total serum IgE levels and severity of atopic dermatitis...I suggest to both groups to study
the work on these matters done by my groups during the years 1887 to 1998! For convenience the references cited
are the best way to do so (3 – 12).
The other point why I am wondering: The authors Niggemann and Laske are members of the charite, Humboldt
University, Berlin, Dean D.Ganten rejecting at the years 1995/6 papers of mine addressing the now raised question
(11).
A third point: I by myself got allergic problems and the level of total IgE in my serum samples are for sure not related
to any degree of eczema: At levels of total IgE as high as 1000 kU/l I had no sign of any skin manifestations – I had
family problems among other things (divorce, job) which relates to psychic factors.
The "Hyper-IgE-Syndrome" is not to correlate with dermatitis. Skin Prick-tests and Epicoutanous-tests do neither...
However...I suggest the measurement of total IgE in the serum of every person as predictive factor for disease development and preventive step.
References
1.Laske N, Niggemann B. Does the severity of atopic dermatitis correlate with serum IgE levels? Pedriatr Allergy
Immunol 2004: 15: 86 – 8.
2.Joishy M, Alfaham M and Tuthill D. Does the severity of atopic dermatitis correlate with serum IgE levels? Pedriatr
Allergy Immunol 2005: 16: 283.
3.Kiehl R, Ionescu G. Pathological changes in platelet histamine oxidases in atopic eczema. Mediators of
Inflammation 1993: 2: 403-406.
4.Kiehl R, Ionescu G, Manuel P, Stern LP, Niemann A, Müller-Steinwachs J. Klinische, immun- und
lipidmodulatorische Effekte einer Behandlung mit ungesättigten Fettsäuren bei atopischer Dermatitis. H+G Zeitschrift
für Hautkrankheiten 1994: 69: 42-48.
5.Kiehl R. Total IgE as a monitoring/response tool to therapy. Int.Alk-Ciba Corning Joint Symposium, Benzheim, oct
28/29: 1994.
6.Kiehl R. Regulation der IgE-Synthese, Proliferation und Entwicklung von AIDS, BIOforum 1997:12: 686-690.
7.Kiehl R. Molecular regulation of IgE synthesis and proliferation: stress protein IgE as early warning signal for our
body. IFCC-Proc. of the 17. Int. Symposium on "The Confluence of Critical Care Analysis and Near Patient
Testing", Nice, June 4-7: 1998: 467-482.
8.Kiehl R. Biotechnology in Bavaria ( Profiles, Portraits, Perspectives ) – Global Partner:
fb-werbeservice@t-online.de, Munich 2001: 45-46.
9.Kiehl R. Molekulare Medizin (Pathobiochemie, Biochemie). Habilthesis, Universität München, Med. Fakultät
(some articles thereout at: www.rki-i.com), 1995.
10.Kiehl R. Reaction mechanisms of osmotically active proton substitute lithium. BioPerspectives, Wiesbaden, and
html- or pdf-files (powerpoint-presentation) under www.rki-i.com 2005.
11.Kiehl R. Further articles under www.rki-i.com , publications (list of publications) and materials (articles, pdf-files)
2001 to now.
12.Kiehl R. Missing Link: Neurotransmitter Lithium. Allergy, AllergyNet, submitted.
Reinhold Kiehl, RKI-Institute, Saliterweg 1, D-93 437 Furth im Wald, phone: +49 9973 801056, kiehl@rki-i.com, www.rki-i.com, www.dr-kiehl.net.